Open Clinical Trials & Investigator-Initiated Studies

For more information about currently open studies or studies that may be opening soon, please contact the Clinical Research Center by phone (207) 973-9033 or e-mail wcurrier@emhs.org.

All Active, IRB-approved Studies by Service Area:
Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery: A Randomized, Blinded Controlled Study.
Implications of Preoperative Psychological Findings in Post Weight Loss Surgery Patient Outcomes.

A Brief Intervention for Mindfulness-Based Relapse Prevention in Primary Care: A Feasibility Pilot Study for Patients in Treatment for Opiate Addiction with Buprenorphine.

 
Bangor Area Access to Quality Care (A2QC).

Partnerships to Improve Community Health (PICH): Northern Maine Rural Collaborative for Healthy Communities.

 
Type 1 Diabetes TrialNet - Natural History Study of the Development of Type 1 Diabetes.

 
APPRENTICE: Acute Pancreatitis Patient Registry to Examine Novel Therapies in Clinical Experience.

Use of Bethanechol Improves Symptoms of Smooth Muscle Contractility and Bolus Transit in Patients with Ineffective Esophageal Motility Disorder.
Geriatric Psychiatry:
A Double-Blind, Placebo-Controlled Study to Examine the Safety and Efficacy of Pimavanserin for the Treatment of Agitation and Aggression in Alzheimer's Disease.

Imaging Dementia--Evidence for Amyloid Scanning (IDEAS) Study: A Coverage with Evidence Development Longitudinal Cohort Study.

A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer's Disease Dementia (The DAYBREAK Study).

Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Patients with Prodromal, Mild, and Moderate Alzheimer's Disease Compared to Healthy Volunteers.


A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of T-817MA in Patients with Mild to Moderate Alzheimer's Disease (US202).

A Phase 3 Safety and Efficacy Study of ALZT‐OP1 in Subjects with Evidence of Early Alzheimer’s Disease.

 
MaineCares: A Partnership for Primary Care Education.

Impact of Reflective Writing on the Development of Interprofessional Communication Skills and Relationships Within Teams.

Mild and Rapidly Improving Stroke Study (MaRISS).

Management of Acute Stroke Patients on Treatment with New Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry.

Long-term, Prospective, Multinational, Parallel-cohort Study Monitoring Safety in Patients with MS Newly Started on Fingolimod Once Daily or Treated with Another Approved Disease-modifying Therapy.
A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System.

A Prospective Post-market, Multi-center Study of the Tritanium® Acetabular Shell.

Screening for Osseous Lesions after Anterior Shoulder Dislocation.

 
Effects of Osteopathic Manipulative Treatment (OMT) on Post-Operative Ileus: A Prospective Study.
The Way to Optimal Weight (WOW): A Multidisciplinary Weight Loss Intervention for Overweight and Obese Children.

The WOW Wellness Academy.

Pediatric Obesity Weight Evaluation Registry (POWER): A Prospective Pilot Project of Children and Adolescents Presenting for Weight Management.

Care Coordination of Services for Children with Autism Spectrum Disorders.


Community-based Outpatient Clinic for Neonatal Abstinence Syndrome Newborns.

Neonatal Abstinence Syndrome, Predictor Factors for Length of Stay.
There are no open studies at this time.
A Brief Intervention for Mindfulness-Based Relapse Prevention in Primary Care: A Feasibility Pilot Study for Patients in Treatment for Opiate Addiction with Buprenorphine.

Integrated Community Care Model Supported by Telehealth Technology.

The Do
wneast Maine Health Consortium.

Advancing Payment Reform in Maine.

 
Geriatric Psychiatry:
A Double-Blind, Placebo-Controlled Study to Examine the Safety and Efficacy of Pimavanserin for the Treatment of Agitation and Aggression in Alzheimer's Disease.

Imaging Dementia--Evidence for Amyloid Scanning (IDEAS) Study: A Coverage with Evidence Development Longitudinal Cohort Study.

A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer's Disease Dementia (The DAYBREAK Study).

Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Patients with Prodromal, Mild, and Moderate Alzheimer's Disease Compared to Healthy Volunteers.

A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of T-817MA in Patients with Mild to Moderate Alzheimer's Disease (US202).

A Phase 3 Safety and Efficacy Study of ALZT‐OP1 in Subjects with Evidence of Early Alzheimer’s Disease.

 
Long-term, Prospective, Multinational, Parallel-cohort Study Monitoring Safety in Patients with MS Newly Started on Fingolimod Once Daily or Treated with Another Approved Disease-modifying Therapy.

Disabilities of the Arm, Shoulder, and Hand (DASH) - Validity and Reliability among Patients Recovering from Stroke.


 
Integrated Community Care Model Supported by Telehealth Technology.
American College of Surgeons Trauma Quality Improvement Program (ACS TQIP®).
Post-Approval Study of Transcarotid Artery Revascularization in Patients with Significant Carotid Artery Disease (The ROADSTER 2 Study).

GREAT - Global Registry for Endovascular Aortic Treatment Outcomes Evaluation.

ARCHYTAS - AAA Registry: Clinical Outcomes of Highly Angulated Anatomy Treated with the Aorfix Stent Graft.